| CYP1A2 抑制剂 | CYP2C9抑制剂 | CYP2C19抑制剂 | CYP2D6抑制剂 | CYP3A4抑制剂 | LogP | PPB | CNS |
gw1 | 0.31 | 0.33 | 0.42 | 0.40 | 0.47 | 2.23 | −2.37 | 80% |
gw2 | 0.35 | 0.31 | 0.41 | 0.28 | 0.48 | 1.85 | −2.65 | 90% |
gw3 | 0.30 | 0.31 | 0.43 | 0.37 | 0.45 | 2.19 | −2.78 | 80% |
gw4 | 0.39 | 0.37 | 0.44 | 0.51 | 0.50 | 3.23 | −2.31 | 92% |
gw5 | 0.39 | 0.37 | 0.44 | 0.51 | 0.50 | 2.23 | −2.31 | 92% |
gw6 | 0.29 | 0.34 | 0.41 | 0.50 | 0.46 | 2.11 | −3.03 | 91% |
gw7 | 0.48 | 0.39 | 0.51 | 0.47 | 0.51 | 2.72 | −2.80 | 97% |
gw8 | 0.27 | 0.35 | 0.37 | 0.37 | 0.48 | 3.39 | −2.56 | 87% |
gw9 | 0.24 | 0.30 | 0.39 | 0.40 | 0.54 | 2.19 | −2.02 | 27% |
gw10 | 0.31 | 0.37 | 0.40 | 0.38 | 0.49 | 1.17 | −3.49 | 51% |
gw11 | 0.26 | 0.31 | 0.39 | 0.39 | 0.46 | 2.00 | −2.18 | 39% |
gw12 | 0.32 | 0.36 | 0.45 | 0.37 | 0.41 | 1.67 | −2.28 | 18% |
gw13 | 0.34 | 0.34 | 0.42 | 0.48 | 0.51 | 1.97 | −2.38 | 43% |
gw14 | 0.28 | 0.33 | 0.38 | 0.37 | 0.50 | 1.59 | −3.61 | 58% |
gw15 | 0.49 | 0.39 | 0.44 | 0.51 | 0.49 | 4.09 | −1.72 | 86% |
gw16 | 0.38 | 0.37 | 0.44 | 0.38 | 0.51 | 1.48 | −2.72 | 82% |
morphine | 0.15 | 0.14 | 0.22 | 0.50 | 0.33 | 0.69 | −2.63 | 35% |