Compd.

¹H NMR (500 MHz, DMSO-d₆), δ

¹³C NMR (500 MHz, DMSO-d₆), δ

4a, 5a

13.84 (0.19H, s, NH), 13.68 (1H, s, NH), 8.64 (d, J = 7.0 Hz, 2H), 8.50 (d, J = 7.0 Hz, 0.41H), 8.09 (s, 1H), 7.97 (d, J = 6.0 Hz, 2H), 7.80 (s, 0.24H), 7.69～7.64 (m, 1H), 7.62~7.54 (m, 2H), 7.47～7.41 (m, 2H), 7.35 (t, J = 7.0 Hz, 0.25H), 7.28 (t, J = 7.0 Hz, 1H)

181.0, 180.8, 145.8, 144.7, 142.9, 136.2, 136.0, 135.7, 133.7, 133.0, 132.9, 132.8, 130.7, 130.5, 128.9, 128.6, 128.5, 128.3, 128.2, 128.1, 127.1, 127.0, 125.7, 124.9, 118.6, 118.5

4b, 5b

13.67 (0.32H, s, NH), 13.53 (1H, s, NH), 8.54 (d, J = 8.0 Hz, 2H), 8.43 (d, J = 8.0 Hz, 0.68H), 7.99 (d, J = 2.0 Hz, 1H), 7.85 (d, J = 8.0 Hz, 0.66H), 7.83 (d, J = 8.0 Hz, 2H), 7.72 (d, J = 2.0 Hz, 0.34H), 7.40 (d, J = 8.0 Hz, 2H), 7.36 (d, J = 8.0 Hz, 0.75H), 7.26(d, J = 8.0 Hz, 0.68H), 7.23 (d, J = 8.0 Hz, 2H), 2.42 (s, 3H), 2.40 (s, 1H), 2.33(s, 1H), 2.32 (s, 3H)

180.4, 180.3, 145.7, 144.7, 143.4, 143.2, 142.9, 137.7, 136.2, 135.7, 133.6, 133.4, 131.0, 130.8, 130.7, 129.4, 129.2, 128.9, 128.7, 128.3, 125.9, 125.6, 124.8, 117.8, 21.2, 20.8

4c, 5c

13.56 (0.26H, s, NH), 13.45 (1H, s, NH), 8.71 (d, J = 8.5 Hz, 2H), 8.57 (d, J = 8.5 Hz, 0.60H), 7.92 (d, J = 1.5 Hz, 1H), 7.89 (s, 0.28H), 7.87 (d, J = 8.5 Hz, 2H), 7.65 (s, 0.26H), 7.13 (d, J = 8.5 Hz, 2H), 7.09 (d, J = 8.5 Hz, 0.70H), 7.02 (s, 0.28H), 6.99 (d, J = 8.5 Hz, 2H), 3.88 (s, 2H), 3.86 (s, 1H), 3.80 (s, 1H), 3.78 (s, 2H)

179.1, 178.9, 163.2, 163.0, 159.3, 158.6, 145.6, 144.7, 142.7, 135.4, 133.1, 132.9, 128.9, 128.7, 127.6, 127.1, 126.5, 126.1, 121.3, 116.9, 114.3, 114.0, 113.6, 113.5, 55.5, 55.2, 55.1

4d, 5d

13.79(0.17H, s, NH), 12.63 (1H, s, NH), 8.71 ( t, J = 6.5Hz, 2H), 8.58( t, J = 6.5 Hz, 0.38H), 8.05 (s, 1H), 8.00 (dd, J = 8.0 Hz, 0.42H), 7.95 ( dd, J = 8.0Hz, 2H), 7.74 (s, 0.18H), 7.40 (t, J = 8.8 Hz, 2H), 7.36 (d, J = 8.0 Hz, 0.35H), 7.29 (d, J = 9.0 Hz, 0.39H), 7.24 (t, J = 8.8 Hz, 2H)

179.0, 166.1, 164.1, 162.5, 160.5, 145.6, 144.5, 142.0, 134.9, 133.6 (d, J = 9.3 Hz), 133.5 (d, J = 9.3 Hz), 132.5 (d, J = 2.8 Hz), 130.1 (d, J = 2.8 Hz), 128.8, 127.9 (d, J = 8.0 Hz), 126.8 (d, J = 8.0 Hz), 118.4, 115.8 (d, J = 21.5 Hz), 115.5-115.2 (m), 115.1

4e, 5e

13.87 (0.15H, s, NH), 13.71 (1H, s, NH), 8.59 (d, J = 7.8 Hz, 2H), 8.50 (s, 0.29H), 8.11 (s, 1H), 7.94 (d, J = 7.9 Hz, 2H), 7.82 (s, 0.27H), 7.67 (d, J = 8.1 Hz, 2H), 7.48 (d, J = 7.9 Hz, 2H)

179.4, 170.3, 144.5, 141.8, 138.2, 137.7, 134.5, 132.6, 132.5, 131.6, 131.5, 131.4, 131.1, 129.6, 128.7, 128.6, 128.5, 127.4, 126.9, 126.5, 119.3

4f, 5f

13.91 (0.14H, s, NH), 13.74 (1H, s, NH), 8.51 (d, J = 8.4 Hz, 2H), 8.42 (d, J = 8.4 Hz, 0.30H), 8.16 (s, 1H), 7.93 (d, J = 8.4 Hz, 0.33H), 7.89 (d, J = 8.4 Hz, 2H), 7.82 (d, J = 8.4 Hz, 2H), 7.79 (d, J = 8.4 Hz, 0.43H), 7.66 (d, J = 8.4Hz, 0.32H), 7.61 (d, J = 8.4 Hz, 2H)

179.7, 174.3, 144.5, 141.8, 134.8, 132.8, 132.6, 132.5, 131.9, 131.5, 131.4, 131.3, 129.6, 129.4, 127.7, 127.4, 126.9, 120.1, 119.3

4g, 5g

14.16 (0.07H, s, NH), 13.97 (1H, s, NH), 8.66 (d, J = 8.5 Hz, 2H), 8.55 (d, J = 8.0 Hz, 0.15H), 8.36 (d, J = 2.0 Hz, 1H), 8.17 (d, J = 8.0 Hz, 0.17H), 8.15 (d, J = 4.0 Hz, 0.10H), 8.11 (d, J = 8.5 Hz, 2H), 8.08 (d, J = 8.5 Hz, 2H), 7.93 (d, J = 8.5 Hz, 0.24H), 7.90 (d, J = 8.5 Hz, 2H)

184.9, 175.5, 149.9, 146.6, 144.5, 143.1, 137.9, 137.5, 136.4, 136.3, 130.7, 126.7, 126.6, 124.2, 123.5, 120.3, 114.6

4h, 5h

14.14 (0.10H, s, NH), 13.91 (1H, s, NH), 8.69 (d, J = 8.0 Hz, 2H), 8.60 (d, J = 8.0 Hz, 0.21H), 8.30 (s, 1H), 8.19 (d, J = 8.0 Hz, 0.21H), 8.13 (d, J = 8.0 Hz, 2H), 7.96 (d, J = 8.0 Hz, 2H), 7.87 (d, J = 8.0 Hz, 0.10 H), 7.84 (s, 0.06H), 7.81 (d, J = 8.0 Hz, 0.23H), 7.76 (d, J = 8.0 Hz, 2H)

180.0, 144.6, 141.6, 139.2, 137.4, 132.5, 132.2, 131.3, 127.5, 127.2, 125.5(d, J = 1.5 Hz), 125.3, 125.2 (d, J = 1.5 Hz), 124.9, 123.3, 122.8, 120.7