指标

非结合型BPA

BPAG

BPAS

实测值^a

预测值

实测值^a

预测值

实测值^a

预测值

C_max (nM)

0.43 (0.3,0.7)

1.35 (0.93, 1.70)^b

286 (173, 386)

367.1 (342.7,399.5)

18 (10.4, 29.9)

29.11 (21.51, 34.92)

1.31 (0.88, 1.66)^c

610 (580, 648)

22.9 (16.6, 27.9)

T_max (h)

1.6 (0.5,2.2)

0.75 (0.64, 0.83)

1.2 (0.8, 2.2)

0.76 (0.74, 0.78)

2.2 (1.2, 5.2)

2.16 (2.16, 2.18)

0.72 (0.67, 0.77)

0.937 (0.933, 0.967)

2.03 (2.00, 2.03)

AUC (nM*h per day)

2.5 (1.4,5.7)

2.39 (1.57, 3.08)

680 (570.8, 1210)

519.0 (488.8, 561.2)

131 (54.9, 298)

47.25 (35.49, 56.01)

4.15 (2.91, 5.15)

1111 (1050, 1210)

179 (117, 179)