Entry
Catalyst
Solvent
(n) chalcone/(n) hydrazide
Temperature
Time
Yield(%)b
1
-
CH3OH
1:1.2
R.T.
24
N.R.c
2
PWA (0.15 mmol%)
CH3OH
1:1.2
R.T.
24
89
3
PMA (0.15 mmol%)
CH3OH
1:1.2
R.T.
24
78
4
50 wt% PWA/MCM-41 (0.15 mmol%)
CH3OH
1:1.2
R.T.
24
55
5
50 wt% PMA/MCM-41 (0.15 mmol%)
CH3OH
1:1.2
R.T.
24
65
6
PWA (0.10 mmol%)
CH3OH
1:1.2
R.T.
24
52
7
PWA (0.05 mmol%)
CH3OH
1:1.2
R.T.
24
60
8
PWA (0.20 mmol%)
CH3OH
1:1.2
R.T.
24
88
9
PWA (0.15 mmol%)
CH2Cl2
1:1.2
R.T.
24
60
10
PWA (0.15 mmol%)
CH3CN
1:1.2
R.T.
24
52
11
PWA (0.15 mmol%)
CH3C6H5
1:1.2
R.T.
24
58
12
PWA (0.15 mmol%)
CH3COOEt
1:1.2
R.T.
24
64
13
PWA (0.15 mmol%)
THF
1:1.2
R.T.
24
43
14
PWA (0.15 mmol%)
C2H5OH
1:1.2
R.T.
24
75
15
PWA (0.15 mmol%)
CH3OH
1:1
R.T.
24
75
16
PWA (0.15 mmol%)
CH3OH
1:1.5
R.T.
24
96
17
PWA (0.15 mmol%)
CH3OH
1:2
R.T.
24
80
18
PWA (0.15 mmol%)
CH3OH
1:1.5
R.T.
12
73
19
PWA (0.15 mmol%)
CH3OH
1:1.5
R.T.
18
82
20
PWA (0.15 mmol%)
CH3OH
1:1.5
R.T.
36
83