方法

公式

阈值

ROR

$\begin{array}{l}\text{ROR}=\frac{\left(\text{a}/\text{c}\right)}{\left(\text{b}/\text{d}\right)}=\frac{\text{ad}}{\text{bc}}\\ \text{SE}\left(\ln \text{ROR}\right)=\sqrt{\left(\frac{1}{\text{a}}+\frac{1}{\text{b}}+\frac{1}{\text{c}}+\frac{1}{\text{d}}\right)}\\ 95\%Cl={\text{e}}^{\ln \left(\text{ROR}\right)\pm 1.96\sqrt{\left(\frac{1}{\text{a}}+\frac{1}{\text{b}}+\frac{1}{\text{c}}+\frac{1}{\text{d}}\right)}}\end{array}$

a ³ 3；

ROR的95%Cl下限 > 1，则提示生成一个信号

MHRA

$\text{PRR}=\frac{\text{a}/\left(\text{a}+\text{b}\right)}{\text{c}/\left(\text{c}+\text{d}\right)}$

${\chi }^2=\frac{{\left(\text{ad}-\text{bc}\right)}^2\left(\text{a}+\text{b}+\text{c}+\text{d}\right)}{\left(\text{a}+\text{b}\right)\left(\text{c}+\text{d}\right)\left(\text{b}+\text{d}\right)\left(\text{a}+\text{c}\right)}$

a ³ 3；

PRR ≥ 2、看到、卡方(c²) ≥ 4，则提示生成一个信号