3组对象IL-6及临床资料比较

指标

pSS伴焦虑抑郁(n = 45)

pSS不伴焦虑抑郁(n = 45)

健康人组(n = 45)

Z/H/χ²值

P值

病程(月)

16.0 (6.0, 48.0)

36.0 (12.0, 60.0)^*

/

2.126

0.034

ESSPIR

5.0 (4.0, 6.0)

3.0 (2.0, 3.0)^*

/

−6.125

<0.001

ESSDAI

6.0 (4.0, 7.0)

2.0 (1.0, 3.0)^*

/

−7.119

<0.001

抗SSA

/

21.957

<0.001

−

1 (2.2)

17 (37.8)^*

/

+

6 (13.3)

9 (20.0)

/

++

6 (13.3)

5 (11.1)

/

+++

32 (71.1)

14 (31.1)^*

/

抗SSB

/

2.954

0.385^¶

−

26 (57.8)

29 (64.4)

/

+

5 (11.1)

8 (17.8)

/

++

1 (2.2)

0 (0)

/

+++

13 (28.9)

8 (17.8)

/

性别

22.804

<0.001

女

42 (93.3)

42 (93.3)

27 (60.0)^*#

男

3 (6.7)

3 (6.7)

18 (40.0)^*#

年龄(岁)

57.00 (49.00, 63.00)

58.00 (52.00, 65.00)

57.00 (51.00, 62.00)

0.423

0.809

SAS

41.00 (36.00, 45.00)

32.00 (25.00, 34.00)^*

32.00 (27.00, 35.00)^*

39.607

<0.001

SDS

41.00 (35.00, 42.00)

29.00 (22.00, 35.00)^*

28.00 (24.00, 34.00)^*

51.475

<0.001

IL-6 (ng/L)

15.68 (5.55, 28.92)

3.65 (1.98, 8.69)^*

1.50 (1.05, 2.34)^*#

72.323

<0.001

IgG (g/L)

16.80 (12.10, 20.50)

13.30 (10.20, 17.20)^*

8.50 (7.70, 10.00)^*#

53.071

<0.001

C4 (g/L)

0.20 (0.16, 0.30)

0.24 (0.18, 0.33)

0.30 (0.21, 0.42)^*

12.951

0.002

CRP (mg/L)

5.00 (4.30, 8.30)

5.00 (0.94, 7.10)

5.00 (4.30, 5.20)

3.292

0.193

ESR (ml/h)

67.00 (30.00, 95.00)

20.00 (10.00, 40.00)^*

15.00 (10.00, 25.00)^*

47.994

<0.001