5	LTBP4	Latent Transforming Growth Factor Beta Binding Protein 4	Key regulator of transforming growth factor beta that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space.
6	IGF1R	Insulin Like Growth Factor 1 Receptor	Function: receptor tyrosine kinase which mediates actions of insulin-like growth factor 1. Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.
7	ACVR1B	Activin A Receptor Type 1B	Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2. Regulating a many physiological and pathological processes.
8	SHC1	SHC Adaptor Protein 1	Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF.
9	HTRA3	HtrA Serine Peptidase 3	Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1.
10	INSR	Insulin Receptor	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes.
11	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	To be deleted, mutated, or overexpressed in several kinds of cancers.
12	HAP1	Huntingtin Associated Protein 1	Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties.
13	RHBDF2	Rhomboid 5 Homolog 2	Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation.
14	IL2RB	Interleukin 2 Receptor Subunit Beta	Receptor for interleukin-2.
15	COL4A1	Collagen Type IV Alpha 1 Chain	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ‘chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen.
16	IGFALS	Insulin Like Growth Factor Binding Protein Acid Labile Subunit	Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
17	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif.
18	COL5A1	Collagen Type V Alpha 1 Chain	Type V collagen is a member of group I collagen.
19	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.
20	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration.
21	COL1A1	Collagen Type I Alpha 1 Chain	Type I collagen is a member of group I collagen.
22	NGFR	Nerve Growth Factor Receptor	Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF.
23	IGFBP2	Insulin Like Growth Factor Binding Protein 2	Inhibits IGF-mediated growth and developmental rates.
24	ENG	Endoglin	Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis.
25	IGFBP4	Insulin Like Growth Factor Binding Protein 4	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.
26	IGFBP5	Insulin Like Growth Factor Binding Protein 5	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.