Group

Subgroups

Number of studies

RR

95%CI

I2

P-interaction

RCTs (n = 6 studies)

Overall

NA

6

2.08

1.31, 3.32

79%

NA

Age

Children

2

1.17

0.37, 3.67

90%

0.65

Adults

4

0.83

0.66, 1.04

25%

Hydrocephalus type

Obstructive

2

0.63

0.47, 0.85

0%

0.03

Communicating

2

0.96

0.68, 1.35

0%

Both

1

0.89

0.66, 1.20

NA

Cohort studies (n = 22 studies)

Overall

NA

22

1.02

0.88, 1.18

90%

NA

Age

Children

14

1.11

0.94, 1.31

91%

0.33

Adults

2

0.76

0.38, 1.51

40%

Hydrocephalus type

Obstructive

13

1.06

0.94, 1.19

56%

0.48

Both

4

1.03

0.62, 1.71

96%

Country

Developed

16

0.97

0.82, 1.15

91%

0.81

Developing

5

1.29

0.96, 1.75

61%

Multinational

1

0.79

0.88, 1.18

NA