| 试验号 | A：提取压力 /MPa | B：提取温度 /℃ | C：提取时间 /min | D：乙醇体积分数 /% | 小檗碱含量 /(mg∙g−1) |
| 1 | −1 | 1 | 0 | 0 | 0.3396 |
| 2 | 0 | 0 | 0 | 0 | 0.4928 |
| 3 | 1 | 1 | 0 | 0 | 0.7769 |
| 4 | 0 | 0 | 0 | 0 | 0.4597 |
| 5 | 0 | 1 | 0 | −1 | 0.6256 |
| 6 | −1 | 0 | 1 | 0 | 0.8628 |
| 7 | 0 | 0 | 1 | −1 | 0.3472 |
| 8 | 0 | 0 | 0 | 0 | 0.6249 |
| 9 | 1 | 0 | −1 | 0 | 0.6717 |
| 10 | 0 | 1 | 1 | 0 | 0.9236 |
| 11 | 0 | 0 | 1 | 1 | 0.7400 |
| 12 | 0 | 0 | 0 | 0 | 0.2428 |
| 13 | 0 | 0 | −1 | −1 | 0.1147 |
| 14 | 0 | −1 | 0 | −1 | 0.5546 |
| 15 | 1 | −1 | 0 | 0 | 0.6335 |
| 16 | −1 | 0 | 0 | 1 | 0.6202 |
| 17 | 1 | 0 | 1 | 0 | 0.4274 |
| 18 | 0 | 0 | −1 | 1 | 0.6219 |
| 19 | −1 | 0 | 0 | −1 | 0.3011 |
| 20 | 1 | 0 | 0 | −1 | 0.5640 |
| 21 | 0 | 1 | −1 | 0 | 0.4698 |
| 22 | −1 | 0 | −1 | 0 | 0.7355 |
| 23 | −1 | −1 | 0 | 0 | 0.6300 |
| 24 | 0 | 0 | 0 | 0 | 0.6268 |
| 25 | 0 | −1 | 1 | 0 | 0.4570 |
| 26 | 0 | −1 | −1 | 0 | 0.3493 |
| 27 | 1 | 0 | 0 | 1 | 0.6878 |
| 28 | 0 | 1 | 0 | 1 | 0.1986 |
| 29 | 0 | −1 | 0 | 1 | 0.6222 |