中药 | 信号通路 | AS相关靶点及基因 |
栀子 [41] | p38/MAPK/NF-KB信号通路 [42] | ABCA1,SR-B1,下,SR-A,TC,TG,LDL [42] |
PI3K信号通路 [42] | IL-6,TNF-α,KLF2 [43] | |
FOS/MAPK信号通路 [43] | iNOS (M1表型) mRNA,IL-1β,Arg-1 (M2表型) mRNA,IL-10 [44] | |
黄芩 [45] | AMPK//Mfn-2/MAPKs信号通路 [46] | Mfn-2,ERK1/2,p38,JNK,NF-κB,AMPK, IL-6,TNF-α,PAI-1,MMP-9 [47] |
四妙勇安汤 [47] | TLR4/MyD88信号通路 [48] | TLR4,MyD88,TNF-α,IL-6 [48] |
NF-κB/NLRP3信号通路 [49] | iNOS,CD197,CD206mRNA,IL-4,IL-18, NF-κB,NLRP3 mRNA [49] | |
TLR4/NLRP3/Caspase-1信号通路 [50] | NLRP3,TLR4,Caspase-1,IL-1β [50] | |
Nrf2/Trx1/TXNIP信号通路 [51] | SOD,MDA,Nrf2,Trx1,TXNIP [51] | |
IκK-β/IκB-α/NF-κB信号通路 [52] | IκK-β,NF-κBmRNA,IκB-αmRNA,NF-κB [52] | |
黄连解毒汤 [53] | MCP-1/CCR2信号通路 [54] | MCP-1mRNA,CCR2mRNA [54] |
TLR7/MyD88/NF-κB信号通路 [55] | TLR7,MyD88,NF-κB,IL-1β,IL-6 [55] | |
PPARγ/NF-κB信号通路 [56] | PPARγ,NF-Κb [56] | |
PPARγ/LXRα/ABCG1信号通路 [57] | IL-1β,TNF-α,LPL,TC,TG,FC,CE,PPARγ, LXRα,AB-CG1 mRNA [57] | |
泻心汤 [58] | TLR9/MyD88/NF-κB p65 [59] | TLR9,MyD88,NF-κB p65,IL-1β,INF-γ [59] |
葛根芩连汤 [60] | NF-κB/NLRP3/Caspase-1 [40] | CD206,ASC,NLRP3,pro-Caspase-1,NLRP3, NF-κB p65 [40] |