剂量 (mg/kg) | 0.3 | 3 | 10 | 20 | |
累计 (mg/kg) | 0.3 | 3.3 | 13.3 | 33.3 | |
No. 1
| 血压BP | 122 | 124 | 119 | 110 |
血压变化BP | 0 | −9 | −18 | * | |
T1/2 | 0 | 243 | 162 |
| |
心跳HR | 110 | 96 | 84 | 86 | |
心跳变化HR | 0 | 6 | 8 | * | |
No. 2 | 血压BP | 105 | 100 | 100 | 92 |
血压变化BP | 0 | −10 | −42 | −69 | |
T1/2 | 0 | 93 | 152 | 330 | |
心跳HR | 117 | 107 | 89 | 78 | |
心跳变化HR | 0 | 0 | −2 | −10 | |
No. 3 | 血压BP | 133 | 130 | 121 | 131 |
血压变化BP | 0 | −7 | −72 | * | |
T1/2 | 0 | 14 | 135 |
| |
心跳HR | 122 | 114 | 107 | 110 | |
心跳变化HR | 0 | 2 | −12 | * | |
平均 | 血压BP | 120 ± 14 | 118 ± 16 | 113 ± 12 | 111 ± 20 |
血压变化BP | 0 ± 0 | −9 ± 2 | −44 ± 27 | ||
T1/2 | 0 ± 0 | 117 ± 116 | 150 ± 14 |
| |
心跳HR | 116 ± 6 | 106 ± 9 | 93 ± 12 | 91 ± 17 | |
心跳变化HR | 0 ± 0 | 3 ± 3 | −2 ± 10 |