lncRNA | Expression | Mechanism | Biological function |
BCAR4 | Up | ERBB2/3 signaling | Promotes breast cancer tamoxifen resistance [13] |
Hedgehog/GLI2 signaling | Promotes breast cancer metastasis [14] | ||
Hippo and Hedgehog signaling | Promotes YAP-dependent glycolysis [15] | ||
LUCAT1 | Up | miR-5582-3p, TCF7L2 and Wnt/β-catenin signaling | Increases stem-like properties of breast cancer cells [16] |
miR-5702 | Increases cell proliferation, metastasis and cell cycle progression, and suppresses cell apoptosis [17] | ||
SPRY4- IT1 | Up | ZNF703 | Promotes cell proliferation and inhibites cell apoptosis [18] |
miR-6882-3p, TCF7L2 | Promotes cell proliferation and stemness [19] | ||
LINC 00511 | Up | miR-185-3p, E2F1 | Promotes cell proliferation, sphere-formation ability, stem factors expression and tumor growth [20] |
miR-150, MMP13 | Promotes cell proliferation, migration and invasion [21] | ||
miR-185, STXBP4 | LINC00511 knockdown restricted cell proliferation, promoted cell apoptosis, and enhanced radiosensitivity [22] | ||
miR-29c, CDK6 | LINC00511 knockdown enhanced paclitaxel cytotoxicity [23] | ||
TINCR | Up | miR-7, KLF4 | Stimulates cell proliferation, anchorage-independent growth and suppresses cell apoptosis [24] |
miR‑589‑3p, IGF1R‑AKT pathway | Promotes cell proliferation, migration and invasion, and inhibites cell apoptosis. [25] | ||
miR-503-5p, EGFR, JAK2-STAT3 signaling | Promotes cell proliferation,invasion, colony formation,and tumor growth [26] | ||
miR-125b | Promotes trastuzumab resistance [27] |