Entry | 温度(℃) | 1a用量(mmol) | 投料比例1a:T:P | 溶剂用量(mL) | 2a收率(%) | 2a纯度(%) |
1 | 0~5 | 2 | 1:0.35:1.3 | 15 | 83.6 | 98.6 |
2 | 5~10 | 2 | 1:0.35:1.3 | 15 | 83.5 | 98.6 |
3 | 10~15 | 2 | 1:0.35:1.3 | 15 | 80.2 | 97.7 |
4 | 15~20 | 2 | 1:0.35:1.3 | 15 | 77.5 | 96.3 |
5 | 5~10 | 2 | 1:0.35:1.0 | 15 | 70.9 | 81.5 |
6 | 5~10 | 2 | 1:0.35:1.1 | 15 | 76.8 | 91.1 |
7 | 5~10 | 2 | 1:0.35:1.2 | 15 | 81.1 | 94.4 |
8 | 5~10 | 2 | 1:0.35:1.25 | 15 | 81.2 | 96.3 |
9 | 5~10 | 2 | 1:0.35:1.35 | 15 | 78.8 | 90.4 |
10 | 5~10 | 2 | 1:0.35:1.4 | 15 | 72.5 | 87.6 |
11 | 5~10 | 2 | 1:0.4:1.2 | 15 | 81.2 | 93.8 |
12 | 5~10 | 2 | 1:0.4:1.25 | 15 | 81.8 | 96.8 |
13 | 5~10 | 2 | 1:0.4:1.3 | 15 | 83.5 | 98.5 |