Denosumab (n = 48)

Zoledronic acid (n = 56)

Median age (years)

65.3 (51~79)

63.1 (55~78)

Pathological method

Radical prostatectomy

10

13

Prostatic puncture

36

41

Bone puncture

2

2

Gleason score

6

4

6

7

8

10

8

8

10

9

14

14

10

14

16

Bone metastasis at first Diagnosis

30

36

Hormone resistance

18

21

Site of bone metastasis

Quadrilateral bone

12

13

Spine

16

19

Multiple bone metastases

20

24

Abnormal renal function

5

6

Spinal cord compression

5

5

Concomitant therapy

Endocrine therapy

42

50

Chemotherapy

10

12

Bone operation

3

2

Radiotherapy

Bone metastasis

15

17

Prostate

18

23

PSA (ug/L)

18 (6.7~55)

16 (7~49)

Basal bone pain (NRS score)

≤3

33

39

4~6

10

7

7~10

5

7

Median duration of medication (month)

12 (8~24)

13 (10~27)