Zoledronic acid

Denosumab

χ²

P

Median pain increase time (month)

(pain score increase ≥ 2 points) (95%, CI)

7.1 (6.278~7.922)

10.4 (8.541~12.259)

8.33

0.004

Onset time of moderate to severe pain (month)

(pain score ≥ 4 points) (95%, CI)

4.8 (3.926~5.674)

6.4 (5.732~7.068)

4.31

0.038