Denosumab (n = 48)

Zoledronic acid (n = 56)

1~2 Grade

3~4 Grade

1~2 Grade

3~4 Grade

Nausea/vomiting

11 (22.9%)

2 (4.2%)

14 (25%)

3 (5.4%)

Diarrhea

3 (6.25%)

2 (4.2%)

5 (8.9%)

1 (1.8%)

Constipation

10 (20.1%)

0

11 (19.6%)

1 (1.8%)

Renal injury

2 (4.2)

0

4 (7.1%)

1 (1.8%)

Urinary tract infection

3 (6.25%)

0

4 (7.1%)

0

Fever

3 (6.25%)

0

10 (17.9%)

1 (1.8%)

Flu-like symptoms

2 (4.2%)

0

12 (21.4%)

0

Fatigue

10 (20.8%)

1 (2.1%)

9 (16.1%)

2 (3.6%)

Hypocalcemia

3 (6.25%)

0

2 (3.6%)

0

Anemia

12 (25%)

2 (4.2%)

14 (25%)

2 (3.6%)