| 不良反应 | I~II级(N，%) | III~IV级(N，%) |
| 食欲减退 | 55 (56.7%) | 0 |
| 甲状腺功能减退 | 32 (32.9%) | 3 (3.1%) |
| 高血压 | 19 (19.6%) | 0 |
| 疲劳 | 43 (44.3%) | 0 |
| 腹痛腹泻 | 14 (14.4%) | 0 |
| 体重下降 | 48 (49.5%) | 0 |
| 手足综合征 | 2 (2.0%) | 0 |
| 蛋白尿 | 30 (30.9%) | 4 (4.1%) |
| 出血 | 6 (6.1%) | 0 |
| 血小板减少 | 35 (36.1%) | 3 (3.1%) |
| 转氨酶升高 | 30 (30.9%) | 3 (3.1%) |
| 血细胞减少 | 45 (46.4%) | 0 |
| 皮疹 | 4 (4.1%) | 1 (1.0%) |