| #15 | RCT |
| #16 | Controlled clinical trial |
| #17 | Clinical trial |
| #18 | #1 or #2 or #3 or #4 or #5 |
| #19 | #6 or #7 or #8 or #9 or #10 |
| #20 | #11 or #12 or #13 or #14 or #15 or #16 or #17 |
| #21 | #18 and #19 and #20 |