变量

基线

3个月

6个月

9个月

12个月

x ± s

x ± s

x ± s

x ± s

x ± s

EORTC QLQ-C30

总体健康情况

69.26 ± 9.38

69.70 ± 10.04

71.70 ± 9.61

72.46 ± 9.88

73.54 ± 9.83

躯体功能

90.48 ± 9.11

88.49 ± 9.34

89.61 ± 8.11

89.78 ± 8.36

90.91 ± 8.52

角色功能

88.74 ± 14.70

83.66 ± 14.14^**

85.82 ± 14.18

86.15 ± 13.53

88.10 ± 14.18

情绪功能

83.93 ± 12.39

82.25 ± 12.11

85.17 ± 11.91^*

86.09 ± 11.40

87.45 ± 12.46

认知功能

86.36 ± 13.62

79.55 ± 16.40^**

83.55 ± 16.77^*

84.42 ± 15.85

86.80 ± 15.16

社会功能

80.63 ± 16.93

79.00 ± 19.54

80.74 ± 18.62

79.44 ± 19.99

78.90 ± 19.09

疲劳

20.20 ± 16.82

21.14 ± 16.35

19.33 ± 18.16

17.17 ± 17.95

16.02 ± 14.93

恶心呕吐

4.55 ± 9.92

4.65 ± 9.59

4.03 ± 8.09

4.00 ± 10.24

3.79 ± 8.60

疼痛

8.33 ± 11.90

9.63 ± 13.27

8.77 ± 11.74

8.55 ± 11.43

8.33 ± 1.59

呼吸困难

7.14 ± 13.68

8.01 ± 14.24

7.79 ± 14.10

7.36 ± 13.82

6.93 ± 13.52

失眠

13.20 ± 18.77

15.80 ± 19.07

14.50 ± 18.96

14.07 ± 17.73

13.64 ± 18.46

食欲丧失

11.25 ± 17.08

12.99 ± 18.34

11.25 ± 17.08

11.04 ± 16.58

10.61 ± 16.43

便秘

10.39 ± 16.35

13.42 ± 18.42

14.72 ± 19.36

14.07 ± 20.38

11.69 ± 17.21

腹泻

10.61 ± 15.52

11.90 ± 15.97

12.77 ± 16.20

10.39 ± 15.44

9.09 ± 14.84

经济困难

24.46 ± 26.60

26.19 ± 24.90

26.84 ± 25.51

24.46 ± 24.63

24.24 ± 24.99

总分

88.23 ± 8.15

85.80 ± 5.43^**

87.06 ± 5.47^*

87.63 ± 5.11

88.62 ± 5.66

HADS

焦虑

4.10 ± 3.50

4.50 ± 3.10

4.30 ± 3.00

3.90 ± 3.00

3.30 ± 3.00

抑郁

4.80 ± 3.70

5.30 ± 3.20

5.10 ± 3.10

4.90 ± 3.40

4.30 ± 3.60