Fixed effect

Coefficient

T-statistic

P-value

REML

ML

REML

REML

Intercept

3.947508

3.944325

22.325188

0.0000

time

−1.313492

−1.313265

−9.638033

0.0000

time2

0.467245

0.467722

7.427107

0.0000

time3

−0.041090

−0.041153

−5.080926

0.0000

treatment

0.667951

0.673348

3.056347

0.0046

time:treatment

−0.114951

−0.116712

−2.478084

0.0139