Entry | R1, R2 | R, M = Li or Na | 19/20 | Yield [%] | Ee [%] |
1 | Ph, Me | 2-Me | 96/4 | 87 | 95 |
2 | Ph, Me | 4-Me | 98/2 | 91 | 95 |
3 | Ph, Me | 4-MeO | 98/2 | 88 | 97 |
4 | Ph, Me | 3-MeO | 95/5 | 84 | 96 |
5 | Ph, Me | 3-Ph | 96/4 | 76 | 95 |
6 | Ph, Me | 2-Ph | 96/4 | 65 | 93 |
7 | Ph, Me | 3-Me2N | 99/1 | 56 | 97 |
8 | Ph, Me | 3,4-(OCH2O) | 99/1 | 65 | 94 |
9 | Ph, Me | 2,4-Me2 | 98/2 | 85 | 95 |
10 | Ph, Me | 2,4,6-Me3 | 93/7 | 82 | 93 |
11 | Ph, Et | 4-Br | 96/4 | 91 | 90 |
12 | Ph, Et | 4-Cl | 93/7 | 96 | 92 |
13 | Ph, Et | 4-Br,3-Me | 95/5 | 89 | 87 |
14 | Ph, Et | 4-CF3 | 90/10 | 92 | 80 |
15 | 2-MeOC6H4, Me | H | 98/2 | 79 | 75 |
16 | 4-MeOC6H4, Me | H | 97/3 | 70 | 86 |
17 | n-Pr, Me | H | 92/8 | 93 | 92 |
18 | n-Pr, Me | 2-Me | 87/13 | 86 | 90 |
19 | n-Pr, Me | 4-MeO | 90/10 | 73 | 85 |