临床资料

所有患者

非ICI组

ICI组

P值

例数(男/女)

227 (140/87)

200 (124/76)

27 (16/11)

0.593

年龄

78.85 ± 12.53

78.58 ± 8.19

79.32 ± 10.11

0.728

COPD/哮喘

25 (11.0%)

22 (11.0%)

3 (11.1%)

0.558

冠心病/高血压

86 (37.9%)

74 (37.0%)

12 (44.4%)

0.056

糖尿病/甲状腺疾病

72 (31.7%)

65 (32.5%)

7 (25.9%)

0.067

肝功能衰竭

23 (10.1%)

20 (10.0%)

3 (11.1%)

0.862

III, IV级手术

38 (16.7%)

33 (16.5%)

5 (18.5%)

0.425

全肠外营养

112 (49.3%)

99 (49.5%)

13 (48.1%)

0.632

ACPACHE II评分[分，M (P25, P75)]

19.0 (15,26)

16.0 (15,26)

19.0 (17,26)

0.027

SOFA评分[分，M (P25, P75)]

10.0 (7.0,15.0)

10.5 (7.0,15.0)

11.0 (8.0,14.0)

0.671

深静脉置管

225 (99.1%)

198 (99.0%)

27 (100.0%)

0.952

有创机械通气

135 (59.5%)

120 (60.0%)

15 (55.5%)

0.652

肾脏替代治疗

58 (25.6%)

50 (25.0%)

8 (29.6%)

0.521

血管活性药物

162 (71.4%)

142 (71.0%)

20 (74.1%)

0.363

WBC (×10⁹/L)

12.20 ± 4.02

12.86 ± 4.86

11.97 ± 4.45

0.286

NC (×10⁹/L)

8.95 3.21

9.01 ± 4.01

8.90 ± 3.52

0.351

LC (×10⁹/L)

2.51 ± 0.78

2.65 ± 0.51

1.92 ± 0.45

0.021

PLT (×10⁹/L)

135.28 ± 95.64

156.52 ± 103.21

114.62 ± 68.52

0.012

C反应蛋白(mg/L)

38.6 ± 10.75

39.11 ± 12.54

37.15 ± 9.65

0.625

降钙素原(μg/L)

2.56 ± 1.20

2.95 ± 2.02

2.48 ± 2.01

0.452

G实验(ng/L)

69.50 ± 15.60

56.33 ± 12.10

118.70 ± 21.33

0.001

IL-6 (ng/L)

40.162 ± 8.26

42.17 ± 9.32

38.65 ± 10.11

0.358

IL-8 (ng/L)

127.60 ± 15.80

130.72 ± 20.11

125.31 ± 12.30

0.625

TNF-α (ng/L)

20.45 ± 8.30

24.65 ± 6.32

20.01 ± 2.56

0.367