Source	Design	Duration (weeks)	Disease	Trial group		Control group		Jadad scale
Source	Design	Duration (weeks)	Disease	Treatment	n	Treatment	n	Jadad scale
Galiè N et al., 2008 ARIES 1 [20]	RCT	12	PAH	Ambrisentan 5/10 mg QD	67/67	placebo	67	4
Galiè N et al., 2008 ARIES 2 [20]	RCT	12	PAH	Ambrisentan 2.5/5 mg QD	64/63	placebo	65	4
Pilar E-S et al., 2018 [21]	RCT	16	CTEPH	Ambrisentan 5 mg QD	15	placebo	13	4
ARTEMIS-PH [23]	RCT	56	IPF	Ambrisentan 10 mg QD	15	placebo	25	4
Zixuan P et al., 2019 [22]	RCT	24	SSC	Ambrisentan 10 mg QD	17	placebo	15	5