ADR outcome | Studies | Participants | RR (95% CI) | Incidence rate (%) | P Value | Effect Model |
Cardiovascular disorders |
| |||||
palpitations | 3 | 433 | 1.45 (0.49~4.25) | 4.2 | 0.5 | Fixed |
Gastrointestinal disorders |
| |||||
abdominal discomfort | 3 | 433 | 1.59 (0.51~4.97) | 4.2 | 0.43 | Fixed |
diarrhea | 2 | 78 | 0.39 (0.1~1.54) | 4.55 | 0.18 | Fixed |
constipation | 4 | 466 | 2.16 (0.72~6.51) | 4.95 | 0.44 | Fixed |
General disorders |
| |||||
peripheral edema | 5 | 504 | 1.58 (1.01~2.45) | 18.94 | 0.04 | Fixed |
nasal congestion | 3 | 433 | 3.25 (1.08~9.79) | 7.34 | 0.006 | Fixed |
flushing | 3 | 433 | 1.75 (0.53~5.79) | 3.85 | 0.36 | Fixed |
epistaxis | 2 | 71 | 1.96 (0.38~9.96) | 11.11 | 0.42 | Fixed |
Infections |
| |||||
sinusitis | 3 | 433 | 2.64 (0.57~12.15) | 3.15 | 0.21 | Fixed |
upper respiratory tract infection | 4 | 466 | 1.39 (0.52~3.71) | 4.29 | 0.5 | Fixed |
Nervous system disorders |
| |||||
headache | 5 | 504 | 1.19 (0.8~1.79) | 18.95 | 0.39 | Fixed |
dizziness | 3 | 111 | 0.22 (0.04~1.12) | 1.64 | 0.07 | Fixed |
Respiratory disorders | ||||||
dyspnea | 3 | 433 | 1.16 (0.56~2.39) | 6.64 | 0.69 | Fixed |