ADR outcome

Studies

Participants

RR (95% CI)

Incidence rate (%)

P Value

Effect Model

Cardiovascular disorders

palpitations

3

433

1.45 (0.49~4.25)

4.2

0.5

Fixed

Gastrointestinal disorders

abdominal discomfort

3

433

1.59 (0.51~4.97)

4.2

0.43

Fixed

diarrhea

2

78

0.39 (0.1~1.54)

4.55

0.18

Fixed

constipation

4

466

2.16 (0.72~6.51)

4.95

0.44

Fixed

General disorders

peripheral edema

5

504

1.58 (1.01~2.45)

18.94

0.04

Fixed

nasal congestion

3

433

3.25 (1.08~9.79)

7.34

0.006

Fixed

flushing

3

433

1.75 (0.53~5.79)

3.85

0.36

Fixed

epistaxis

2

71

1.96 (0.38~9.96)

11.11

0.42

Fixed

Infections

sinusitis

3

433

2.64 (0.57~12.15)

3.15

0.21

Fixed

upper respiratory tract infection

4

466

1.39 (0.52~3.71)

4.29

0.5

Fixed

Nervous system disorders

headache

5

504

1.19 (0.8~1.79)

18.95

0.39

Fixed

dizziness

3

111

0.22 (0.04~1.12)

1.64

0.07

Fixed

Respiratory disorders

dyspnea

3

433

1.16 (0.56~2.39)

6.64

0.69

Fixed