Group

24 h

48 h

72 h

α-SMA

n = 12

TGF-β

n = 12

Collagen 1

n = 12

α-SMA

n = 12

TGF-β

n = 12

Collagen 1

n = 12

α-SMA

n = 12

TGF-β

n = 12

Collagen 1

n = 12

ctrl

1.0 ± 0.19

1.0 ± 0.14

1.0 ± 0.13

1.03 ± 0.22

1.06 ± 0.24

0.93 ± 0.09

1.09 ± 0.30

1.08 ± 0.17

0.96 ± 0.20

TGF-β

5 ng/mL

1.50 ± 0.58^**

0.69 ± 0.19^**

1.20 ± 0.29^*

1.87 ± 0.08^**

0.81 ± 0.27

1.52 ± 0.36

1.86 ± 0.55^**

0.42 ± 0.14^**

1.43 ± 0.25^*

TGF-β

10 ng/mL

2.4 ± 0.35^**

0.59 ± 0.04^**

1.70 ± 0.41^*

2.79 ± 0.27^**

0.19 ± 0.03

2.41 ± 0.34

3.39 ± 0.35

0.55 ± 0.21^**

2.16 ± 0.24^*

CKZ

10 ul/mL

0.57 ± 0.16^*

0.16 ± 0.14^***

0.18 ± 0.06^*

0.69 ± 0.21^*

0.22 ± 0.10

0.30 ± 0.16

0.90 ± 0.25^**

0.22 ± 0.09^***

0.42 ± 0.11^*

CKZ

20 ul/mL

0.36 ± 0.05^*

0.16 ± 0.08^***

0.13 ± 0.25^*

0.24 ± 0.03^*

0.04 ± 0.02

0.16 ± 0.07

0.26 ± 0.08^*

0.17 ± 0.08^***

0.20 ± 0.01^*

TGF-β

+ CKZ

10 ng/mL

+ 20 ul/mL

1.18 ± 0.18^#

0.47 ± 0.12^#

0.61 ± 0.29^#

1.18 ± 0.19^#

0.47 ± 0.05^#

0.73 ± 0.11

1.11 ± 0.54^#

0.35 ± 0.19^#

0.60 ± 0.34^#